Delayed preconditioning-mimetic actions of exercise or nitroglycerin do not affect haemodynamics and exercise performance in trained or sedentary individuals     

Antonio Crisafulli  Franco Melis  Filippo Tocco  Gianluigi Pittau  Luigi Lorrai  Tommaso Gori 《Journal of sports sciences》2013,31(12):1393-1401

Abstract

Nitroglycerin induces the so-called second window of protection (SWOP), which alleviates myocardial damage and stunning after ischaemia/reperfusion. To determine whether myocardial performance during exercise is improved in the second window of protection, we studied the haemodynamic responses of 12 trained and 11 sedentary individuals during a sequence of maximal tests on a cycle ergometer. A baseline test (basal test) was followed by a second effort performed during the second window of protection (exercise-SWOP test). Haemodynamics was also evaluated after pharmacologically induced SWOP 48 h after transdermal administration of 10 mg of nitroglycerin (pharmacologically induced SWOP test). The exercise-SWOP and pharmacologically induced SWOP tests were separated by a 1-week washout period. Endothelial-dependent vasodilatation after nitroglycerin pre-treatment was also assessed in five sedentary individuals to determine whether nitrate donors could affect vascular function. We found that nitroglycerin pre-treatment did not induce any improvement in haemodynamics in either trained or sedentary individuals, since maximum values of workload, heart rate, stroke volume, cardiac output, myocardial contractility, and double product were similar between the exercise-SWOP and pharmacologically induced SWOP tests in both groups. Furthermore, nitroglycerin pre-treatment did not alter flow-mediated dilation during pharmacologically induced SWOP. Although nitroglycerin pre-treatment alleviates post-ischaemic myocardial stunning, our results suggest that it does not affect the myocardial performance of healthy individuals during exercise performed in the second window of protection, independently of the training status of the individuals. Moreover, nitroglycerin pre-treatment does not ameliorate endothelial function.  相似文献   

运动性和高血压性心脏肥大心肌间质胶原网络重塑及其对左心室功能的影响     

魏晓峰  魏伟  史娇娇  贾斯媛  周丹丹 《广州体育学院学报》2013,33(3):81-86

目的:探讨运动性和高血压性心脏肥大大鼠心肌间质胶原网络的重塑及其对左心室功能的影响.方法:采用跑台训练方式和腹主动脉缩窄术分别建立运动性心肌肥大大鼠模型和高血压性心肌肥大大鼠模型.心脏离体灌注测定左心室功能;扫描电镜和透射电镜观察心肌胶原网络重构;通过羟脯氨酸测定心肌胶原的浓度;Western-blot进行Ⅰ型、Ⅲ型胶原分析.结果:高血压大鼠的平均动脉压始终较高(P＜0.05),而训练组大鼠的动脉血压始终较低(P＜0.05);高血压大鼠的心脏舒张速率低于训练组(P＜0.05);高血压性大鼠左心室羟脯氨酸的浓度明显升高(P＜0.05),而训练大鼠左心室羟脯氨酸浓度并没有显著升高;高血压大鼠的左心室Ⅲ型胶原与Ⅰ型胶原的比值下降明显(P＜0.05),而训练组大鼠并没有表现出相同的结果.结论:运动训练可以使大鼠心肌细胞与间质胶原同步增长,心脏功能提高,心肌舒缩性能增强;而慢性高血压性大鼠导致心肌细胞与间质胶原不成比例的增长,间质胶原过度增生,心脏功能受到损伤.心肌间质胶原网络的重塑对大鼠左心室功能具有重要影响.  相似文献   

急性心肌梗塞的心电图诊断——附5例报告     

程秀红 《北京体育大学学报》1991,(3)

结合临床,对5例心肌梗塞患者心电图的变化进行了分析与诊断,尤其是对一些在心电图上不出现典型改变而易漏诊的心肌梗塞病例进行了分析.  相似文献   

间歇性和持续性游泳训练对大鼠心肌肌球蛋白Ca~(2+)-ATP酶活性的影响     

徐玉林 《广州体育学院学报》1998,(1)

采用大鼠强制游泳的方法 ,研究了高强度间歇训练和持续性训练对大鼠心肌肌球蛋白Ca2 + -ATP酶活性的影响。 6周训练后 ,以上两训练组大鼠的心肌肌球蛋白Ca2 + -ATP酶活性均增强 ,且间训组增长幅度更大 ,证明运动强度比运动时间对肌球蛋白Ca2 + -ATP酶活性的影响更强 ;特训组雌鼠比雄鼠心肌肌球蛋白Ca2 + -ATP酶活性的增长幅度大 ,提示心肌收缩蛋白在对运动强度和时间的适应方面 ,存在性别差异。  相似文献   

大鼠心肌收缩性能在两种方式训练后的改变   总被引：1，自引：0，他引：1  

徐玉林 《广州体育学院学报》1998,(3)

两组大鼠分别经 6周高强度无氧间歇性 (AT)及耐力性 (ET)游泳训练后 ,应用颈动脉插管法 ,测试在体心脏左室心肌力学指标。结果显示 :ET组大鼠心肌收缩性能及舒张性能均有提高 ;AT组心肌收缩性能有所减弱 ,舒张性能明显减弱。提示耐力训练促进心肌收缩性能增强 ;长期的高强度无氧训练可能导致心肌功能下降 ,尤以舒张性能降低较为明显。  相似文献   

Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction     

陶则伟  黄元伟  夏强  傅军  赵志宏  陆贤  BRUCE I.C 《浙江大学学报(A卷英文版)》2004,5(4):494-498

Objective: Myocardial infarction (MI) is the main cause of heart failure, but the relationship between the extent of MI and cardiac function has not been clearly determined. The present study was undertaken to investigate early changes in the electrocardiogram associated with infarct size and cardiac function after MI. Methods: MI was induced by ligating the left anterior descending coronary artery in rats. Electrocardiograms, echocardiographs and hemodynamic parameters were assessed and myocardial infarct size was measured from mid-transverse sections stained with Masson's trichrome. Results: The sum of pathological Q wave amplitudes was strongly correlated with myocardial infarct size (r = 0.920, P < 0.0001), left ventricular ejection fraction (r = (0.868, P < 0.0001) and left ventricular end diastolic pressure (r = 0.835, P < 0.0004). Furthermore, there was close relationship between MI size and cardiac function as assessed by left ventricular ejection fraction (r = (0.913, P < 0.0001) and left ventricular end diastolic pressure (r = 0.893, P < 0.0001). Conclusion: The sum of pathological Q wave amplitudes after MI can be used to estimate the extent of MI as well as cardiac function.  相似文献   

自体血浆回输疗法治疗脑梗塞的临床研究     

陈菊英  白鹰  宋晶  刘文祥  华宗祥  吕恒宝  韩毅  祝玉岩  席惠君  韩姝坤 《大连大学学报》1994,(1)

自体血浆回输治疗脑梗塞的方法是在国内外血液稀释疗法基础上进行了改进,此法采静脉血200ml,分离后去掉血球,血浆当即回输。本文用此法治疗急性脑梗塞30例,并与对照组低分子右旋糖酐组(简称右酐组)和蝮蛇抗栓酶组(简称血浆回输组)症状和体征缓解时间明显快于对照组,其显效率及有效率明显高于对照组,多项血液流变学指标均有明显改善。  相似文献   

脐带血干细胞移植治疗急性心肌缺血的实验研究     

李春海 《河北北方学院学报(医学版)》2005,22(4):43-44

目的:利用人脐带血干细胞移植治疗兔急性心肌缺血,探索防治缺血性心脏病的新方法.方法:新西兰白兔40只,雌雄不拘.随机等分为实验组和对照组.两组均结扎冠状动脉左前降支中1/2,复制心肌梗死模型.缺血60min后将0.3ml的108/ml人脐带血干细胞注射到实验组兔的缺血区心肌组织,对照组兔缺血区心肌组织中注射等体积的人静脉血.3周后观察心功能、心肌梗死面积和心肌生化指标.结果:实验组的LVSP和左心室最大变化速率均明显高于对照组(P＜0.01),而LVEDP显著低于对照组(P＜0.01).实验组的心肌梗死面积明显小于对照组(P＜0.01),血清CK和MDA的含量也显著低于对照组(P＜0.01),SOD含量则明显高于对照组(P＜0.05).结论:人脐带血干细胞移植能够明显改善兔急性心肌缺血的心功能,减轻氧自由基对心肌的损伤,缩小心肌梗死面积.  相似文献   

AMI患者PCI术对血浆BNP水平变化的初步临床观察   总被引：1，自引：0，他引：1  

李方江  赵九安  徐涛  杨文粹  王亚玲  梁海峰  宋郁珍  牛发良  乎东波 《河北北方学院学报(医学版)》2005,22(1):56-57

目的:观察PCI术对AMI患者血浆中BNP的水平变化,初步探讨PCI对AMI患者预后的影响.方法:采用快速荧光免疫测定法对20例AMI患者PCI治疗前后和20例对照组血浆BNP水平进行检测.结果:AMI患者血浆BNP在AMI患者PCI术与对照组比较有显著性差异(P＜0.05),PCI治疗后呈明显下降趋势.结论:AMI患者PCI治疗血浆BNP水平变化说明PCI术能对改善AMI患者的预后有重要意义.  相似文献   

舒血宁配合治疗急性脑梗死的临床观察     

薛茜  陈晓春 《河北北方学院学报(医学版)》2004,21(2):11-13

目的:观察舒血宁注射液对急性脑梗死的治疗效果以及对患者血液流变学的影响,综合分析其作用机理.方法:将60例急性脑梗死患者随机分为两组:舒血宁注射液加常规药物治疗组(治疗组)30例,常规药物治疗组(对照组)30例.观察两组患者治疗后有效率、治疗前后神经功能缺损评分以及血液流变学变化.结果:治疗组总有效率86.7%,平均减少积分为(9.33±4.47)分,明显优于对照组的63.4%、(8.50±4.60)分(P＜0.05);在降低全血粘度、全血还原粘度、血浆粘度、红细胞聚集指数、红细胞压积、红细胞刚性指数及升高红细胞变形指数方面与对照组相比,差异有显著性(P＜0.05).结论:舒血宁做为急性脑梗死联合用药,可明显提高临床疗效,其作用机制与扩张血管、降低血液粘度有关,安全可靠.  相似文献